The hypofunction of NMDA receptors (NMDARs) in schizophrenia could arise from the occlusion of GluN2B-containing NMDARs by the CABT complex,
which consists of a CRMP2 monomer, an alpha and a beta tubulin. Tubulin is the canonical binding partner of CRMP2. Binding between GluN2B and CRMP2 has been demonstrated experimentally
(Al-Hallaq et al., 2007).